Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins
نویسندگان
چکیده
منابع مشابه
Regulation of peptidoglycan synthesis by outer membrane proteins
Growth of the mesh-like peptidoglycan (PG) sacculus located between the bacterial inner and outer membranes (OM) is tightly regulated to ensure cellular integrity, maintain cell shape, and orchestrate division. Cytoskeletal elements direct placement and activity of PG synthases from inside the cell, but precise spatiotemporal control over this process is poorly understood. We demonstrate that P...
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Section of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Texas, USA Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Texas, USA Cellular and Molecular Biology Program, Institute for Cellular and Molecular Biology, University of Texas at Austin, Texas, USA Dep...
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The bacterial cell envelope contains the stress-bearing peptidoglycan layer, which is enlarged during cell growth and division by membrane-anchored synthases guided by cytoskeletal elements. In Escherichia coli, the major peptidoglycan synthase PBP1A requires stimulation by the outer-membrane-anchored lipoprotein LpoA. Whereas the C-terminal domain of LpoA interacts with PBP1A to stimulate its ...
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ژورنال
عنوان ژورنال: Cell
سال: 2010
ISSN: 0092-8674
DOI: 10.1016/j.cell.2010.11.038